The Risk of Lethal Prostate Cancer Couldn’t Reduce with Diet Change

According to a study, there may be a link between nutrition, the gut microbiome, and fatal prostate cancerTrusted Source. The Cleveland Clinic study was published in Cancer Epidemiology, Biomarkers & Prevention. The researchers analysed data from the PLCO cancer screening trialTrusted Source, a 148,000-person randomised control trial. It entailed screening 76,685 men aged 55 to 74 for prostate cancer and following up with them for up to 13 years. Nearly 700 males were studied for their baseline levels of specific Diet ary components and metabolites. Prostate cancer claimed the lives of 173 of them.

The researchers compared those who died to controls in a 1:3 ratio for age, race, blood sample time, and enrolment date. 83.6 percent of the 519 men in the control group stayed healthy, whereas 16.4 percent had non-lethal prostate cancer over the research period. All participants in the PLCO cancer screening experiment supplied blood samples when they signed up. Researchers looked for various distinct metabolites in blood serum, some of which are generated by gut bacteria as a result of food consumption.

They compared the outcomes of men who died of prostate cancer with those of healthy men. The researchers discovered links between three metabolites – phenylacetylglutamine, choline, and betaine – and more aggressive prostate cancer. When gut bacteria break down phenylalanine, an important amino acid, phenylacetylglutamine is generated. Choline and betaine are found in some meals and are produced by gut microbes.

High protein foods, such as dairy, meat, poultry, soy, fish, beans, nuts, and Diet sodas sweetened with aspartame, contain phenylalanine. It is a component of many proteins and enzymes in the body and is utilised to generate the neurotransmitter dopamine when converted to tyrosine.